Scientists demonstrate AI-designed enzyme for drug synthesis
ChemistryPharmacyBiology
THE AI ANGLE
Designing custom enzymes for chemical synthesisResearchers used an artificial intelligence model called RFD4-Proteina to design synthetic enzymes for manufacturing the HIV drug lenacapavir. Laboratory tests showed the top candidate converted 79 percent of a chiral amine into the target product with high selectivity. Chemists can now generate tailored biocatalysts computationally for complex reactions instead of modifying natural proteins.
THE TEACHING ANGLE
Students can examine how an enzyme active site favors amide bond formation while blocking a competing reaction with excess water.Read the original at phys.org Generate teaching or study materials
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